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Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist State governments · Private institutions of higher education · Independent school districts · Native American tribal organizations (other than Federally recognized tribal governments) · Public housing authorities/Indian housing authorities · City or township governments · County governments · Special district governments · For profit organizations other than small businesses · Native American tribal governments (Federally recognized) · Public and State controlled institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Small businesses · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications seeking to develop new capabilities should focus on significant enhancement of the spatial resolution, depth of delivery, and/or precision of the device. Incremental changes to existing devices (e.g., software updates)are not within the scope of this announcement. Applications should be submitted by multi-disciplinary teams with a variety of expertise including systems neuroscience, engineering, clinical, and regulatory affairs.
Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)
Vereinigte Staaten · US
Wer antragsberechtigt ist Private institutions of higher education · Public and State controlled institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification)
The purpose of this Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for undergraduate students and enhancing the research environment at applicant institutions. Eligible institutions must award baccalaureate science degrees and have received no more than $6 million dollars per year of NIH support (in both direct and F and A/indirect costs) in 4 of the last 7 fiscal years. For institutions composed of multiple schools and colleges, the $6 million funding limit is based on the amount of NIH funding received by all the non-health professional schools and colleges within the institution as a whole. This Notice of Funding Opportunity (NOFO) supports investigator-initiated mechanistic and/or minimal risk clinical trials addressing the mission and research interests of the participating NIH institutes. For the purpose of this NOFO, minimal risk clinical trials are defined as those that do not require FDA oversight, do not intend to formally establish efficacy, and have low risks to potentially cause physical or psychological harm.
Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist Small businesses · City or township governments · County governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public and State controlled institutions of higher education · Special district governments · State governments · Native American tribal organizations (other than Federally recognized tribal governments) · Private institutions of higher education · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · For profit organizations other than small businesses · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Independent school districts · Native American tribal governments (Federally recognized) · Public housing authorities/Indian housing authorities
The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications seeking to develop new capabilities should focus on significant enhancement of the spatial resolution, depth of delivery, and/or precision of the device. Incremental changes to existing devices (e.g., software updates) are not withinthe scope of this announcement.
NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist Special district governments · County governments · Native American tribal organizations (other than Federally recognized tribal governments) · Small businesses · Private institutions of higher education · City or township governments · State governments · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Public housing authorities/Indian housing authorities · Native American tribal governments (Federally recognized) · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · For profit organizations other than small businesses · Public and State controlled institutions of higher education · Independent school districts · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
This NIDCR Small Grant Program for New Investigators supports basic and clinical research conducted by scientists who are in the early stages of establishing an independent research career in oral, dental and craniofacial research. This R03 program supports pilot or feasibility studies and developmental research projects with the intention of obtaining sufficient preliminary data for a subsequent investigator initiated Research Project Grant (R01) or equivalent application.
NICHD Small Research Grant Program (R03 Clinical Trial Required)
Vereinigte Staaten · US
Wer antragsberechtigt ist County governments · City or township governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Independent school districts · Native American tribal governments (Federally recognized) · State governments · For profit organizations other than small businesses · Special district governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Small businesses · Native American tribal organizations (other than Federally recognized tribal governments) · Private institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities
The NICHD Small Research Grant Program (Clinical Trial Required) supports clinical trials that fall within the NICHD mission.
Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist County governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Special district governments · Small businesses · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · City or township governments · Native American tribal governments (Federally recognized) · Public housing authorities/Indian housing authorities · State governments · Public and State controlled institutions of higher education · Private institutions of higher education · Independent school districts · Native American tribal organizations (other than Federally recognized tribal governments) · For profit organizations other than small businesses
This Notice of Funding Opportunity (NOFO) encourages grant applications from investigators interested in conducting basic, mechanistic research into the biological/genetic causes of cancer health disparities. These research project grants will support innovative studies designed to investigate biological/genetic bases of cancer disparities, such as (1) mechanistic studies of biological factors associated with cancer disparities, including those related to basic research in cancer biology or cancer prevention strategies, (2) the development and testing of new methodologies and models, and (3) secondary data analyses. This NOFO is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can expand available resources and tools, such as biospecimens, patient derived models, and methods that are necessary to conduct basic research in cancer health disparities.
NCMRR Early Career Research Award (R03 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Independent school districts · Special district governments · County governments · Small businesses · Native American tribal governments (Federally recognized) · Public housing authorities/Indian housing authorities · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · State governments · City or township governments · Public and State controlled institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Private institutions of higher education · Native American tribal organizations (other than Federally recognized tribal governments) · For profit organizations other than small businesses
The National Center for Medical Rehabilitation Research (NCMRR) Early Career Research (ECR) Award (R03) is intended to support both basic and clinical research from rehabilitation scientists who are establishing independent research careers. The research must be focused on one or more of the areas within the mission of NCMRR: Applicants are encouraged to refer to the NIH Research Plan on Rehabilitation for strategic priorities (https://www.nichd.nih.gov/newsroom/news/110121-NIH-rehab-plan). The NCMRR ECR Award R03 grant mechanism supports various types of projects including secondary analysis of existing data; small, self-contained research projects; development of research methodology; translational research; outcomes research; and development of new technology. Irrespective of the type of project, the intent of the NCMRR ECR Award R03 is for the Program Director(s)/Principal Investigator(s) (PD(s)/PI(s)) to obtain sufficient preliminary data for a subsequent R01 application.
Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Small businesses · County governments · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Private institutions of higher education · City or township governments · Native American tribal governments (Federally recognized) · Special district governments · Native American tribal organizations (other than Federally recognized tribal governments) · Independent school districts · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public housing authorities/Indian housing authorities · State governments · For profit organizations other than small businesses · Public and State controlled institutions of higher education
This notice of funding opportunity (NOFO) encourages innovative research to develop, improve, characterize, and preserve animal models as well as animal model related biological materials, technologies, and new approach methodologies (NAMs) for studies relevant to human health and disease. This NOFO also seeks projects aimed at improving the diagnosis and control of diseases that could confound or interfere with animal use in biomedical research. The proposed project must have broad applicability to multiple NIH Institutes or Centers (ICs) to align with the NIH-wide mission of the Office of Research Infrastructure Programs (ORIP). The proposed studies must include animal models and explore multiple body systems or multiple categories of diseases. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC, will be considered not acceptable to this NOFO and will be withdrawn.
Focused Technology Research and Development (R01 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist State governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public housing authorities/Indian housing authorities · Native American tribal governments (Federally recognized) · Small businesses · City or township governments · Independent school districts · Public and State controlled institutions of higher education · Native American tribal organizations (other than Federally recognized tribal governments) · For profit organizations other than small businesses · County governments · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Private institutions of higher education · Special district governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
This Notice of Funding Opportunity (NOFO) supports projects relevant to the NIGMS mission that focus solely on the development of technologies with potential to enable acquisition of biomedical knowledge. Projects should be justified in terms of technical innovation and utility of such technical innovation for impacting future biomedical research. Outcomes or products of the proposed project should significantly advance the current state of the art and be sufficiently characterized for application in addressing a broad range of biomedical research questions.
NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist Small businesses · State governments · Public housing authorities/Indian housing authorities · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Private institutions of higher education · City or township governments · For profit organizations other than small businesses · Native American tribal governments (Federally recognized) · Special district governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Native American tribal organizations (other than Federally recognized tribal governments) · Independent school districts · County governments · Public and State controlled institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification)
The purpose of the NIDCR Dentist Scientist Career Transition Award for Intramural Investigators (K22) program is to facilitate transition of highly qualified dentists from NIH Intramural postdoctoral research positions to extramural academic tenure-track or equivalent faculty positions at eligible institutions. The award will provide support for two years of mentored postdoctoral research training in the NIH Intramural Research Program, and three years of independent research funding at the extramural institution.
Laboratories to Optimize Digital Health (R01 Clinical Trial Required)
Vereinigte Staaten · US
Wer antragsberechtigt ist Private institutions of higher education · City or township governments · Independent school districts · Public housing authorities/Indian housing authorities · Public and State controlled institutions of higher education · Native American tribal organizations (other than Federally recognized tribal governments) · Special district governments · State governments · For profit organizations other than small businesses · County governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Native American tribal governments (Federally recognized) · Small businesses · Others (see text field entitled "Additional Information on Eligibility" for clarification)
NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions. This NOFO is intended to support the development of digital health test beds that leverage well-established digital mental health platforms,to rapidly refine and optimize existing evidence-based digital health interventions and conduct clinical trials testing digital mental health interventions that are statistically powered to provide a definitive answer regarding the intervention's effectiveness.
Modular R01s in Cancer Control and Population Sciences (R01 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Private institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Public housing authorities/Indian housing authorities · Native American tribal governments (Federally recognized) · Special district governments · City or township governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · County governments · Native American tribal organizations (other than Federally recognized tribal governments) · Small businesses · State governments · Public and State controlled institutions of higher education · Independent school districts · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · For profit organizations other than small businesses
This Notice of Funding Opportunity (NOFO) encourages applications for research in cancer control and population sciences. The overarching goal is to provide support to promote research efforts on novel scientific ideas that have the potential to substantially advance cancer research in statistical and analytic methods, epidemiology, cancer survivorship, cancer-related behaviors and behavioral interventions, healthcare delivery, and digital health and data science, and implementation science.
NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist Native American tribal organizations (other than Federally recognized tribal governments) · For profit organizations other than small businesses · County governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Independent school districts · Special district governments · Public and State controlled institutions of higher education · Native American tribal governments (Federally recognized) · State governments · Small businesses · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · City or township governments · Public housing authorities/Indian housing authorities · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Private institutions of higher education
The purpose of this award is to support outstanding scientific training of highly promising postdoctoral candidates with outstanding mentors. Candidates are eligible to apply for support from this program from ~12 months prior to the start of the proposed postdoctoral position to within 12 months after starting in postdoctoral position. Based on the early timeframe of eligibility, and the discouragement of inclusion of preliminary data, this NINDS F32 seeks to foster early, goal-directed planning and to encourage applications for bold and/or innovative projects by the candidate that have the potential for significant impact. Applications are expected to incorporate strong training in quantitative reasoning and the quantitative principles of experimental design and analysis. Support by this program is limited to the first 3 years of a candidate's activity in a specific laboratory or research environment, so as to further encourage early fellowship application and timely completion of mentored training of the postdoctoral candidate in a single environment.
Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Independent school districts · Public and State controlled institutions of higher education · For profit organizations other than small businesses · Public housing authorities/Indian housing authorities · Small businesses · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Native American tribal organizations (other than Federally recognized tribal governments) · County governments · City or township governments · Native American tribal governments (Federally recognized) · Private institutions of higher education · Special district governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · State governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
The purpose of this Notice of Funding Opportunity (NOFO) encourages applications that will expand knowledge of the natural history of disorders that currently are, or may become, part of statewide newborn screening programs. A comprehensive understanding of the natural history of a condition is necessary to facilitate appropriate interventions for infants identified by newborn screening. Characterization of the sequence and timing of symptom development provides information crucial for developing targeted, age-appropriate treatments and for establishing a baseline against which to assess novel interventions. In addition, for some conditions, establishment of genotype-phenotype correlations may facilitate prediction of the clinical course; for others, identification of modifying genetic, epigenetic, or environmental factors may enhance understanding of clinical outcomes. Comprehensive data on the natural history of a condition will facilitate the fields ability to: 1) identify the underlying biological mechanisms; 2) understand the genetic and clinical heterogeneity and phenotypic expression of the condition; 3) improve diagnostic accuracy; 4) facilitate clinical trials by providing comprehensive natural history data; 5) prevent, manage, and treat symptoms and complications of the condition; 6) furnish physicians and families with needed support and predictive information about the condition; and 7) establish data collection systems or patient registries to collect longitudinal data (e.g., child/family outcomes following newborn screening).
Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Private institutions of higher education · Independent school districts · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public and State controlled institutions of higher education · Small businesses · State governments · County governments · Native American tribal organizations (other than Federally recognized tribal governments) · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Special district governments · Native American tribal governments (Federally recognized) · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Public housing authorities/Indian housing authorities · For profit organizations other than small businesses · City or township governments
The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects. This FOA supports basic, translational, and clinical research projects that seek to identify the mechanisms of therapy-induced adverse sequelae, clinically characterize the adverse sequelae, or translate the mechanistic understanding into therapeutic approaches to prevent or minimize the development of long-term sequelae. Research projects should focus on mechanistic studies with translational endpoints and longitudinal clinical phenotyping to identify and validate clinical endpoints (biomarkers, imaging, patient-reported outcomes, or combined elements) for future use in clinical trials that will evaluate the efficacy of interventions designed to prevent or reduce specific adverse sequelae.
Molecular Imaging of Inflammation in Cancer (R01 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist County governments · Private institutions of higher education · State governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities · City or township governments · Special district governments · Native American tribal governments (Federally recognized) · Native American tribal organizations (other than Federally recognized tribal governments) · Independent school districts · For profit organizations other than small businesses · Small businesses · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
The purpose of this Notice of Funding Opportunity (NOFO) is to invite research grant applications (R01) for the development and use of current and emerging molecular imaging methods to gain fundamental insights into cancer inflammation in vivo. The motivation for this initiative is that much of current imaging research into the role of inflammation in cancer is largely based on in vitro and ex vivo methods with limited utilization of imaging approaches that could lead to significant new insights relevant to dynamic cancer and inflammation interactions. Utilization of molecular imaging probes in pre-clinical and clinical investigations for precise temporal resolution at the molecular and cellular level are valuable approaches for identification and characterization of in vivo inflammatory cellular physiology in cancers and of molecular changes in response to treatment. This FOA encourages applications that focus on developing integrated imaging approaches to interrogate the role of inflammation in cancer through strong cross-field collaboration between cancer basic science researchers and imaging scientists. These collaborations are expected to advance science and understanding of cancer inflammation interactions.
Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy (R01 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Special district governments · City or township governments · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · For profit organizations other than small businesses · Independent school districts · State governments · Small businesses · Public and State controlled institutions of higher education · County governments · Native American tribal governments (Federally recognized) · Private institutions of higher education · Native American tribal organizations (other than Federally recognized tribal governments) · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public housing authorities/Indian housing authorities
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) seeks research project (R01) grant applications describing projects that integrate imaging and fluid-based tumor monitoring (liquid biopsy) assays during cancer therapy in patients to determine the optimal use of those modalities in the characterization of therapy response and/or emergence of resistance.
Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Native American tribal organizations (other than Federally recognized tribal governments) · Independent school districts · City or township governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Special district governments · For profit organizations other than small businesses · County governments · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · State governments · Public housing authorities/Indian housing authorities · Private institutions of higher education · Public and State controlled institutions of higher education · Small businesses · Native American tribal governments (Federally recognized)
The purpose of this Funding Opportunity Announcement (FOA) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged.All applications must be within the scope of the mission of one of the Institutes/Centers listed above.
Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Vereinigte Staaten · US
Wer antragsberechtigt ist State governments · Independent school districts · Public housing authorities/Indian housing authorities · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · City or township governments · Others (see text field entitled "Additional Information on Eligibility" for clarification) · For profit organizations other than small businesses · Special district governments · Small businesses · Public and State controlled institutions of higher education · Native American tribal governments (Federally recognized) · County governments · Native American tribal organizations (other than Federally recognized tribal governments) · Private institutions of higher education · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This Notice of Funding Opportunity (NOFO) encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden for promoting optimal longer-term outcomes. This NOFO is intended to support effectiveness trials testing post-acute phase interventions that are statistically powered to provide a definitive answer regarding the study intervention's effectiveness. Support for pilot effectiveness trials to evaluate the initial feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches is provided via a companion R34 (Currently TEMP-24814)
Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Vereinigte Staaten · US
Wer antragsberechtigt ist County governments · Special district governments · For profit organizations other than small businesses · Native American tribal organizations (other than Federally recognized tribal governments) · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities · Native American tribal governments (Federally recognized) · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Private institutions of higher education · City or township governments · Independent school districts · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Others (see text field entitled "Additional Information on Eligibility" for clarification) · State governments · Small businesses
NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden. In this pilot phase of effectiveness research, the trial should be designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach; to address whether the intervention engages the target(s)/mechanisms(s) that is/are presumed to underlie the intervention effects; and to obtain preliminary data needed as a pre-requisite to a larger-scale effectiveness trial (e.g., comparative effectiveness study, practical trial) designed to definitely test the effectiveness of interventions to improve post-acute outcomes. This Notice of Funding Opportunity (NOFO) supports pilot effectiveness research to evaluate the feasibility, tolerability, acceptability, safety and preliminary indications of effectiveness of post-acute phase intervention approaches and inform the design of definitive effectiveness trials. Support for fully-powered, definitive effectiveness studies focused on post-acute phase interventions is provided via the R01 currently TEMP-24813.
Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist Others (see text field entitled "Additional Information on Eligibility" for clarification) · Independent school districts · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Small businesses · County governments · City or township governments · Special district governments · State governments · Native American tribal organizations (other than Federally recognized tribal governments) · Native American tribal governments (Federally recognized) · Private institutions of higher education · Public and State controlled institutions of higher education · Public housing authorities/Indian housing authorities · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · For profit organizations other than small businesses
The purpose of this Funding Opportunity Announcement (FOA) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies. Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged. All applications must be within the scope of the mission of one of the Institutes/Centers listed above.
Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)
Vereinigte Staaten · US
Wer antragsberechtigt ist For profit organizations other than small businesses · Public housing authorities/Indian housing authorities · Others (see text field entitled "Additional Information on Eligibility" for clarification) · Special district governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · County governments · Native American tribal organizations (other than Federally recognized tribal governments) · State governments · City or township governments · Small businesses · Independent school districts · Private institutions of higher education · Public and State controlled institutions of higher education · Native American tribal governments (Federally recognized)
Rapid advances in genotyping and next generation sequencing technologies have led to the identification of genetic variants that are associated with a wide variety of congenital defects including human congenital anomalies (HCAs), intellectual developmental disabilities (IDDs) and inborn errors of metabolism (IEMs). Large quantities of genomic data collected from pediatric congenital anomalies cohorts are available to the research community through several databases such as the Database of Genotypes and Phenotypes (dbGaP), the Gabriella Miller Kids First Data Resource Portal, the European Genome-Phenome Archive and Clinical Genome Resource (ClinGen). The purpose of this initiative is to promote the screening, functional validation and characterization of congenital anomaly-associated genetic variants identified through public facing databases and individual efforts using in-silico tools, appropriate animal models, in vitro systems or multi-pronged approaches. This initiative addresses a challenging gap between identifying sequence variations of potential interest and recognizing which of those variations have functional effects on the phenotype of interest.
Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist For profit organizations other than small businesses · Others (see text field entitled "Additional Information on Eligibility" for clarification) · County governments · Private institutions of higher education · State governments · City or township governments · Native American tribal governments (Federally recognized) · Independent school districts · Small businesses · Native American tribal organizations (other than Federally recognized tribal governments) · Public housing authorities/Indian housing authorities · Special district governments · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public and State controlled institutions of higher education · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
The purpose of this Notice of Funding Opportunity (NOFO) is to support studies that will identify, develop, and/or test strategies for overcoming barriers to the adoption, adaptation, integration, sustainability, scale-up, and spread of evidence-based interventions, practices, programs, tools, treatments, guidelines, and policies (hereafter referred to as evidence-based interventions). Conversely, there is a benefit in understanding circumstances that create a need to stop or reduce (de-implement) the use of practices that are ineffective, unproven, low-value, or harmful. In addition, studies to advance dissemination and implementation research methods and measures are encouraged. Applications that focus on re-implementation of evidence-based health services that may be disrupted amidst disasters (e.g., pandemics) remain relevant. All applications must be within the scope of the mission of one of the Institutes/Centers listed above.
Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)
Vereinigte Staaten · US
Wer antragsberechtigt ist Others (see text field entitled "Additional Information on Eligibility" for clarification) · Native American tribal governments (Federally recognized) · Native American tribal organizations (other than Federally recognized tribal governments) · Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education · Public and State controlled institutions of higher education · City or township governments · Public housing authorities/Indian housing authorities · Private institutions of higher education · State governments · Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education · Independent school districts · For profit organizations other than small businesses · County governments · Special district governments · Small businesses
The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies.
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