Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)

Description

The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers.

Official source

Eligible beneficiaries

• Small businesses
• Special district governments
• Others (see text field entitled "Additional Information on Eligibility" for clarification)
• Public housing authorities/Indian housing authorities
• Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
• Public and State controlled institutions of higher education
• Independent school districts
• Native American tribal organizations (other than Federally recognized tribal governments)
• Private institutions of higher education
• For profit organizations other than small businesses
• State governments
• City or township governments
• Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
• County governments
• Native American tribal governments (Federally recognized)